Some links are out of date - I apologise for that!

Generic modelling software

  • ModelMaker
    • A cheap, commercial software. Unfortunately it's not maintained anymore (best under Windows XP).
    • Good for dynamic models and parameter estimation
    • It's very robust, versatile and easy to learn. Highly recommended.
  • OpenModel
    • Free software, developed by Neil Crout at the University of Nottingham, UK
    • Similar to ModelMaker
    • Advantage: MCMC parameter estimation
  • MathCAD
    • Commercial, but well worth it's money
    • Flexible and very transparent modelling
    • Also very good for day to day calculations
  • NetLOGO
    • Individual (or agent) based modelling made easy
    • Great fun, easy to learn and surprisingly powerful

Software implementation of GUTS

openGUTS standalone WINDOWS executable
openGUTS standalone WINDOWS executable

OpenGUTS is a user-friendly software to perform analyses with GUTS: the General Unified Threshold model for Survival. GUTS is the leading toxicokinetic-toxicodynamic framework for the endpoint survival (and other non-reversible all-or-nothing effects). 

This site hosts the software itself, as a standalone Windows executable, with manuals and background documentation. Since openGUTS is (as the name implies) open source, also the source files can be obtained here. Additionally, you can download the Matlab version, which served as the blueprint for the standalone version. The Matlab version has basically the same functionality, and can be easily adapted or extended to perform customised analyses. Finally, we provide (links to) further information on openGUTS and GUTS. The main features of the software are:

  1. Open and free: the software is open source and freely downloadable. The fully-functional Matlab version that served as the prototype is also available.
  2. User-friendly: fit models and derive confidence intervals without requiring user interaction (e.g., no need for starting values).
  3. Robust: always find the global optimum and relevant intervals, even for awkward data sets.
  4. Flexible: allow time-varying exposure, missing data, simultaneous fitting on multiple data sets, etc.
  5. Efficient: rapid screening of exposure profiles (e.g., FOCUS output) by batch processing.
  6. Supportive: the software follows the workflow as laid down in the 2018 EFSA opinion on TKTD models.